Hydroalcoholic extract of Arum orientale ameliorates myocardial infarction induced by isoproterenol in rats

Abstract

Arum species have antioxidant, antimicrobial, and anti-cancer effects. However, there is no study on its possible cardioprotective effects. In the present study, the protective effects of hydro-alcoholic extract of Arum orientale(A. orientale) on isoproterenol-induced myocardial infarction (MI) were evaluated. For induction of MI the rats were received isoproterenol (100 mg/kg) for two consecutive days, whereas treated groups received 40, 80 and 160 mg/kg/day of hydroalcoholic extract of A.orientale intraperitoneally (ip) 20 min before each Isoproterenol injection. Isoproterenol-induced MI significantly increased myocardial necrosis and neutrophil infiltration. Histopathological analysis showed that A. orientale at dose of 160 mg/kg significantly reduced necrosis and neutrophil infiltration in the heart tissue (P< 0.046 and P