Mechanism of antinociceptive action of syringic acid

Abstract

Syringic acid presents various biological properties such as antioxidant, anti-inflammatory, anticancer,and other activities. The present experiment aimed to investigate the effect of the oral administration of syringic acid(10, 50, and 100 mg/kg) on its possible nociceptive response using hot-plate and tail-flick assay in the Balb-C micemodel. The mice were pre-treated with 5 mg/kg atropine 15 min before, 1mg/kg mecamylamine 20 min before, 1mg/kgketanserin 30 min before, 1 mg/kg ondansetron 30 min before, 1mg/kg yohimbine 30 min before, 1 mg/kg prazosin 30min before and 5 mg/kg naloxone 15min before the administration of the Syringic acid. Dose-dependent antinociceptiveactivity of syringic acid was reported for 50 and 100 mg/kg doses in tail-flick and hot-plate assays, respectively. Infurther, mecamylamine, yohimbine, and naloxone significantly reversed syringic acid-induced response to thermalstimuli in tail-flick and hot-plate assays, respectively. From the data, it was confirmed that syringic acid presents centralantinociceptive effects which may be coordinated by supraspinal/spinal mediated cholinergic, opioidergic, andadrenergic, inflection.