Paraoxonase (PON1) L55M and Q192R Polymorphisms in Major Depressive Disorder and Bipolar Disorder

Abstract

Objective: Oxidative and nitrosative stress pathways, along with immune-inflammatory response, might play animportant role in the pathogenic mechanisms underlying major depressive disorder and bipolar disorder. The aim of thepresent study is to investigate paraoxonase 1 polymorphisms and its correlations with disease parameters in patientswith major depressive disorder and bipolar disorder.Methods: PON1 L55M and Q192R single nucleotide polymorphisms were analyzed in a group consisted of 100 patientswith major depressive disorder, and 100 patients with bipolar disorder and 96 healthy controls. Polymorphisms wereanalyzed by using polymerase chain reaction.Results: There were no statistically significant differences between groups for the existence of PON1 genotypes.Additionally, there was no association between the PON1 genotypes and disease variables in both depressed and bipolarpatients.Conclusions: Evaluating the different stages of patients with mood disorders and examining the connection betweenPON1 polymorphisms and treatment outcomes will help us to clarify the relationship between PON1 and mood disorders.