Can persistent hiccups be a progression marker in COVID-19?

Abstract

Hiccup is a reflex action that may rarely be intractable. A 55-year-old man diagnosed with COVID-19 was hospitalized to our clinicwith body temperature elevation, weakness, and headache persisting for the previous three days. Persistent hiccups were presentduring follow-up, and progression was observed at pulmonary tomography with an increase in the numbers and dimensions of focalground glass areas. Lymphocyte count was 920/µL, platelet count 138×103/µL, sedimentation rate 6 mm/h, ferritin 1256 ng/mL,C-reactive protein 16.8 mg/L, aspartate aminotransferase 43 U/L, alanine aminotransferase 67 U/L, and lactate dehydrogenase 326U/L. Other potential causes of persistent hiccups were excluded. COVID-19 immune plasma and remdesivir therapy were initiated.The hiccups resolved two days after treatment, and the patient was discharged on the 11th day of follow-up. Persistent hiccups shouldbe remembered among the symptoms that may appear during the clinical progression of COVID-19.