Evaluation of National Early Warning System for Mortality in Hematological Malignancy Patients Admitted to Intensive Care Unit: Prospective, Single Center, Observational Study

Abstract

Objective: Hematological malignancies (HM) are the cause of many deaths worldwide and the incidence isincreasing day by day. New treatment models increase remission rates; but complications that require intensivecare unit (ICU) are also increasing. The aim of this study was to investigate the effect of The National EarlyWarning System Score (NEWSS) on ICU mortality in HM patients.Methods: This study was performed prospectively in the medical ICU. Patients transferred from hematologyward to the medical ICU were included in the study. NEWSS was calculated at the hematology ward beforepatients admitted to the ICU.Results: A total of 91 patients were enrolled in the study with a median (IQR) age of 55 (29) years. The median(IQR) NEWSS was 8 (3). Independent risk factors for ICU mortality were requirement of renal replacementtherapy (P= 0.008), high Sequential Organ Failure Assessment (SOFA) score (P=0.002), development ofAcute Respiratory Distress Syndrome (ARDS) (P=0.005). ICU mortality rate was 62%.Conclusion: Requirement of renal replacement therapy, high SOFA score and development of ARDS wereimportant risk factors for ICU mortality in HM patients. The NEWSS was not found as a risk factor for ICUmortality in HM patients.