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Journals / Journal of Cell and Molecular Biology / 2002 / Cilt: 1 - Sayı: 2

Adriamisinin in vitro ve in vivo koşullarda Ehrlich ascites tümör hücrelerine etkisi

The effect of adriamycin on Ehrlich ascites tumor cells in vitro and in vivo

Gülruh ULAKOĞLU

Pages
87–91
DOI
—

Abstract

The effect of different doses of adriamycin (ADM), was investigated in vitroand in vivo, in Ehrlich ascites tumor (EAT) cells which developed in the peritoneal cavity of mice. In the in vivoexperiments it was found that injection of ADM as 10 mg/g i.p. prolonged the survival period of mice. In the in vitro experiments, treatment of ADM in 2, 4 and 6 mg/ml doses, it was observed that cytotoxic effect dependent on time occurred in tumor cells.

Özet

Adriamisinin (ADM) çeşitli dozlarının farelerin periton boflluğunda gelişen Ehrlich ascites tümör (EAT) hücrelerine etkisi in vivove in vitro olarak denendi. In vivodeneylerde farelere 10 mg/g dozda i.p. olarak enjekte edilen ADM in farelerin yaşam süresini uzattığı saptandı. In vitro deneylerde EAT hücreleri 2, 4 ve 6 mg/ml dozda ADM ile muamele edildiğinde, zamana bağlı olarak tümör hücrelerine sitotoksik etki meydana geldiği gözlendi.