Anticancer Efficiency of Curcumin on Ovarian Cancer

Abstract

Objectives: Ovarian cancer is one of the most common malignancies in women, and it is quite difficult to cure. In order to treat the disease,chemotherapy is often performed as adjuvant therapy following the surgery or neo-adjuvant cure for the pre-operative purpose. While thestrategy is an effective way to destroy the tumor, it also affects healthy cells thus it causes side effects leading to even multiple organ failure anddeath. So that to minimize the disadvantage of chemotherapeutics, phytochemicals have been studied as chemotherapeutic agents. Curcuminis an orange-yellow nutraceutical, which is isolated from turmeric (Curcuma longa L.). This phyto-polyphenolic compound has various roles inbio-industry such as textile and food dye as well as a wide range of medicinal properties especially the anticancer feature.Methods: The aim of this study is to investigate the anti-proliferative and anti-migrative effects of curcumin on ovarian adenocarcinoma. Cellproliferation rates on ONCO-DG-1 cell line were examined in five different doses of curcumin. Wound healing assay was performed to evaluatethe anti-migrative effect on curcumin on this cell line.Results: The results showed that curcumin inhibits tumor cell proliferation at 5, 10, 20, 30 and 40 µM doses at 24- and 48-hours incubationtime (p