Immunoglobulin M-enriched immunoglobulin application in gram-negative sepsis

Abstract

Gram negative sepsis is associated with a mortality 20 to 70% in patients developing septic shock signs. Endotoxin is partly the reason of this high mortality. The endotoxin acts with activating intravascular coagulation, fib-rinolysis, triggering the complement pathways, releasing cytokines and interleukins. Antibiotic therapy alone cannot reverse evolving gram-negative shock because of its delayed effect on endotoxine release through inhibition of bac¬terial growth and cell death. Neutralisation of endotoxin is the main target of the therapeutic interventions in these patients. In this report we present a case of septic shock in which Immunoglobulin M (IgM) enriched Immunoglobulins treatment was successful.