The results of radioactive iodine therapy for Basedow-Graves disease

Ekrem ALGÜN, Adil AZEZLİ, Ferihan ARAL, Senay MOLVALILAR, Ergin SENCER, Neşe ÖZBEY, Yusuf ORHAN, Cihangir EREM

Abstract

The aim of this study is to evaluate relationships between the dose of radioiodine (RAI) and occurrence of hypothyroidism and other clinical parameters in Graves' patients treated with RAI. Forty-eight patients with hyperthyroid Graves' disease (28 females, 20 males; age range- 26-76 yr, mean age(SD= 48.3 ± 12.1 yr) treated with RAI were included in this study. After withdrawal of antithyroid drug therapy for 5 days, RAI was given in arbitrary doses, regarding the size of the thyroid. The patients were evaluated in two separate groups according to RAI dose. First group (n:20): patients given less than 20 mCi (10-19 mCi) RAI. Second group (n:28) patients given more than 20 mCi (20-30 mCi) RAI. The frequency of hypothyroidism after RAI therapy were 65% and 71.4% in groups 1 and 2, respectively (p=0.43). Maintenance of euthyroid state was observed in 20% and 21% of patients in group 1 and 2, respectively (p=0.59). Hyperthyroid state persisted in 3 patients of group 1 (15%) and 2 patient of group 2 (7%) (p=0.33). The time elapsed to the development of hypothyroidism after RAI therapy was 7.5 ± 5.0 months in group I and 3.4 ± 2.5 months in group 2 (p

Özet

Bu çalışmada radyoaktif iyot (RAI) ile tedavi edilen Basedow-Graves'li hastalarda RAI dozu ile tedavi sonrası hipotiroidi gelişme süresi ve klinik parameterler arasındaki ilişkinin değerlendirilmesi amaçlandı. RAI ile tedavi edilen Basedow-Graves'li 48 hasta (28 kadın, 20 erkek, yaş aralığı= 26-76 yıl, yaş ortalaması= 48.3 ± 12.1 yıl) çalışmaya alındı. RAI, antitiroid ilaç tedavisinin en az 5 gün süre ile kesilmesinin ardından tiroid büyüklüğü dikkate alınarak belirlenen arbitrer dozlarda verildi. Hastalar verilen RAI dozuna göre 2 gruba ayrılarak değerlendirildi. I. grup (n:20): RAI dozunun