Kardiyoaktif dekapeptid molekülünün yapısal organizasyonunun konformasyonel analizi

Abstract

Conformational behavior of cardioactive decapeptide Prol-Asp2-Val3-Asp4-His5-Val6-Phe7-Leu8-Arg9-Phel0-NH2 that was isolated from the thoracic nervous system of the locust was investigated by theoretical conformational analysis. Possible structure of the cardioactive decapeptide under physiological conditions may be described by a set of low-energy conformations belonging to 12 different forms of the back bone. Calculations yielded the values of all dihedral angles of the back bone and side chains of the decapeptide various forms as well as intra- and interresidue interaction energies. The low energy conformations of the cardioactive decapeptide were used for a solution of the "reverse conformational problem" for cardioactive modified synthetic analogues.

Özet

Çekirgenin göğüs sinir sisteminden izole edilen kardiyoaktif dekapeptidin yapısal özellikleri teorik yapısal analiz yoluyla araştırıldı. Kardiyoktif dekapeptidin düşük enerjili konformasyonu, değiştirilmiş kardiyoaktif sentetik analoglar için geri dönüşümlü yapısal problemin çözümü için kullanıldı.