Evaluation of serum thiol/disulfide homeostasis in patients with ankylosing spondylitis by a novel method

Erdal DOĞAN, Özcan EREL, Günseli KARACA ACET, Almila AYDIN, Erkan CÜRE, Adem KUCUK, Ahmet OMMA, Ayça TUZCU, Medine Cumhur CÜRE, Rabia Aydoğan BAYKARA

Abstract

OBJECTIVE: Increased reactive oxygen species may play an important role in Ankylosing spondylitis (AS) etiopathogenesis.The thiol group is a very potent antioxidant. In this study, we aimed to investigate the presence of oxidative stress in patientswith AS by evaluating thiol/disulfide homeostasis.METHODS: In this study, a total of 66 AS patients (27 male, 39 female) and 66 healthy controls (21 male, 45 female) wereenrolled. Recently, a novel method for the thiol measurement was found. Thiol and disulfide values were measured by thenovel methods.RESULTS: Native thiol (NT) (p