A practical marker to determining acute severe ulcerative colitis: CRP/albumin ratio

Abstract

OBJECTIVE: There are many instruments to measure disease activity in ulcerative colitis. While determining clinical activityaccording to these instruments, many clinical and laboratory parameters are needed to be followed. Determination of diseaseactivity with non-invasive and objective inflammatory indicators may be a practical and objective way. CRP/Albumin ratio(CAR) is an inflammatory marker that is considered to have prognostic value in various cancers, sepsis and acute pancreatitis. In this study, we aim to investigate diagnostic performance CAR in determining the clinical severity of ulcerative colitis.METHODS: Between November 2011 and February 2017, hospital records and follow-up cards of patients with ulcerativecolitis were reviewed retrospectively. One hundred forty-nine patients were included in this study. Patient’s demographic data,laboratory values, clinical disease activity, according to Truelove & Witts criteria and endoscopic activity according to the Mayosub-score and treatments, were recorded. Diagnostic performance of CAR analyzed to determine the clinical severity.RESULTS: Of the patients included in this study, 99 (62%) were male, and 50 (38%) were female. Mean age was 45.22±14years. When patients were grouped into remission, mild, moderate and severe disease according to disease activity, there wasa statistically significant difference between CRP, CAR, erythrocyte sedimentation rate (ESR) and albumin levels (p=0.001;p