Detection of human immunodeficiency virus (HIV) RNA in the sweat of HIV-infected patients

Abstract

OBJECTIVE: Human immunodeficiency virus (HIV) infection is a significant health problem. Many studies reported that HIVwas mainly transmitted through parenteral exposure, sexual activity, and body secretions, such as saliva and semen. Manypeople, including health-care providers and patient relatives, may easily contact with the sweat of HIV-infected patients.Although reference books assert that HIV does not transmit through sweat, to our knowledge, there is no systemic studywhich this statement is based upon. This study aims to investigate the potential of sweat to transmit HIV infection.METHODS: This study included 31 treatment-naive HIV RNA-positive patients who were in the acute phase of the infectionand 26 subjects with a negative HIV RNA test who had received antiviral treatment. A total of 57 sweat samples collectedfrom intact skin areas were prospectively evaluated by polymerase chain reaction (PCR) for the presence of HIV RNA. HIVRNA levels in the blood samples were also noted.RESULTS: HIV RNA was not detected by PCR in any sweat sample taken from HIV-infected HIV RNA-negative and -positive subjects.CONCLUSION: The findings obtained in this study suggest that sweat by itself has no potential for transmitting HIV infection.