The effects of resveratrol treatment on caveolin-3 expression and $Na^+$ /$K^+$ ATPase activity in rats with isoproterenol-induced myocardial injury

Abstract

OBJECTIVE: The present study aims to investigate the therapeutic effects of resveratrol (RES) on isoproterenol (ISO) induced myocardial injury rat model.METHODS: Catecholamine-induced heart damage was induced by ISO treatment for 30 days. The rats were divided intofour groups as follows: the control group received saline, the ISO group received 5.0 mg/kg ISO, the RES group received 10mg/kg RES, and the ISO-RES group received 10 mg/kg RES and 5 mg/kg ISO treatments for 30 days. Following echocardiographic measurements and body weight recorded, the rats were decapitated. Plasma and cardiac tissue samples obtained bydecapitation were analyzed using biochemical, histopathological, molecular and immunohistochemical methods.RESULTS: In the ISO group, Na+/K+ ATPase activity and ATP content, GSH, and caveolin-3 levels were low. LDH, CK and lysosomal enzyme activities, MDA level, and MPO activity were found to be high. It was determined that GSH and MDA levels and MPO,Na+/K+ ATPase activity, ATP content caveolin-3 levels changes that arose from ISO treatment were suppressed by RES treatment.CONCLUSION: RES treatment has ameliorated all the functional and biochemical parameters. The results obtained in thisstudy suggest that RES is a promising supplement against catecholamine exposure as it improves antioxidant defense mechanisms in the heart. In the light of above-mentioned data, RES can be assumed as a promising agent in ameliorating theoxidative injury of the myocardium.