The effect of low and high dose empagliflozin on HbA1c and lipid profile in type 2 diabetes mellitus: A real-world data

Abstract

OBJECTIVE: This study aims to evaluate the efficacy and safety of the addition of 10 or 25 mg of empagliflozin to patientswith type 2 diabetes mellitus using a maximum tolerable dose of metformin and gliclazide.METHODS: A total of 60 patients who had been receiving a maximum tolerable dose of metformin plus gliclazide. wasdivided into two groups in this study. In the first group (Group 1, n=32), 10 mg empagliflozin was added to the current treatment once a day, and in the second group (Group 2, n=28) 25 mg empagliflozin was added to the same treatment once a day.Biochemical results, weight and blood pressure changes of the patients in both groups were evaluated before and after 12weeks of empagliflozin addition. Patients who developed urinary tract and genital infections after treatment were recorded.RESULTS: There was a statistically significant decrease in HbA1c in both groups after empagliflozin treatment (Group 1,p0.05). Patients in Group 1 and Group 2 lost 2.6±1.2 and 3.8±2.0 kg of body weight,respectively (p