Relationship between local and systemic inflammatory response and prognosis in laryngeal squamous cell carcinoma

Abstract

OBJECTIVE: Laryngeal squamous cell carcinoma (LSCC) is the most frequently seen head and neck malignancy. Despiteimprovements in the treatment modalities within the last 20 years, the desired improvement in survival outcomes has notbeen achieved yet which led researchers to investigate factors that might affect prognosis in LSCCs.METHODS: A total of 116 previously operated patients were included in this study. To assess systemic inflammation, neutrophil/lymphocyte ratio (NLR) and platelet/lymphocyte ratio (PLR) were calculated. The cut–off values for NLR and PLR wereaccepted as 2.79 and 112, respectively. To evaluate intratumoral inflammation, hematoxylin-eosin stained tumor sectionswere evaluated. Tumor-infiltrating lymphocyte (TIL) densities in the tumor area were scored as 1+, 2+ and 3+.RESULTS: The mean overall survival was 29.5±17.7 months. In univariate analysis, a statistically significant correlation wasseen between age group of 60 years, tumor stage, site and OS (p=0.025, p=0.026, p=0.029). There was no statisticallysignificant relationship between PLR, NLR and TIL density and OS. In the multivariate analysis, the 60-year-old group andtumour stage were still significantly associated with the OS (p=0.033, p=0.046).CONCLUSION: Age and tumor stage were significantly associated with survival in our study, but contrary to the literature,no correlation was found between local and systemic inflammatory response.