A case of autoimmune hepatitis following pegylated interferon treatment of chronic hepatitis delta

Abstract

Autoimmune hepatitis may be frequently associated with chronic hepatitis C (HCV) infection, but there are few case reportsregarding hepatitis B and Delta infection (HBV+HDV) as possible triggers. In this report, we present a 44 years old man whowas diagnosed as autoimmune hepatitis (AIH) following the treatment of HBV+HDV hepatitis with pegylated interferon (PegIFN). He presented with complaint of fatigue. Laboratory indicated elevated liver enzymes, AST 64IU/L and ALT 112IU/L.The results revealed HBsAg and anti-delta antibody positivity. HBV-DNA was