Journals / İstanbul Kanuni Sultan Süleyman Tıp Dergisi / 2016 / Cilt: 8 - Sayı: 2
Retrospective Clinical and Etiological Evaluation of Children Diagnosed with Bicytopenia in Clinic of Children’s Health and Diseases of Kanuni Sultan Süleyman Training and Research Hospital: A Single Center Experience
- Pages
- 75–80
- DOI
- —
Abstract
Introduction: Etiology of bicytopenia can be examined within a wide spectrum ranging from temporary viral suppression to malignant infiltration of bone marrow. In our study, we aimed to investigate retrospectively the patients who applied to our hospital and diagnosed with bicytopeni, with etiological and clinical features. Material and Methods: Fifty-eight patients with the age range of 2-17 years and diagnosed with bicytopenia between January 2011 and March 2012 were analyzed retrospectively. Patients’ complaints, physical examinations, blood count, peripheral blood semar findings, Ebstein Barr Virus, Cytomegalovirus, parvovirus B19, Salmonella and Brucella agglutination test results, antinuclear antibody, anti-double-stranded DNA, bone marrow aspiration results were recorded. Results: Fifty-eight patients (28 female, 30 male) were enrolled in the study. The mean ages were 6.5 (± 4.0) years for girls and 8.8 (± 3.6) for boys. The most frequent compliants were fatigue, fever, upper respiratory tract infection symptoms (sneezing, watery eyes, cough, fever), bone pain, dyspeptic complaints and bruises. The most frequent physical examination findings were pallor, lymphadenopathy, splenomegaly, fever, hepatomegaly, upper respiratory tract infection symptoms and ecchymosis. Etiologies of bicytopenia were detected as; acute leukemia (48.3%), B12 vitamin deficiency (5.2%), Brucella infection (3.4%), storage disease (1.7%), portal hypertension (1.7%), aplastic anemia (1.7%), systemic lupus erythematosus (1.7%), and unknown causes (36.2%). Discussion and Conclusion: Peripheral blood smear should be performed and malignant causes must be excluded in all patients presenting with bicytopenia. Viral etiologies of the upper respiratory tract infection should be kept in mind as frequently encountered causes of bicytopenia.
Özet
Amaç: Bisitopeni nedenleri, geçici viral baskılanmadan malign kemik iliği infiltrasyonuna bağlı baskılanmaya kadar olabilen geniş bir yelpazede incelenebilmektedir. Çalışmamızda hastanemize başvuran ve bisitopenisi saptanan hastaların etiyolojik ve klinik olarak retrospektif incelenmesi amaçlanmıştır.Gereç ve Yöntem: Ocak 2011-Mart 2012 tarihleri arasında bisitopeni saptanan yaşları 2-17 yıl olan 58 hasta retrospektif olarak incelendi. Hastaların başvuru yakınmaları, fizik muayene bulguları, kan sayımları, periferik yayma bulguları, Ebstein Barr Virus, Sitomegalovirus, Parvovirus B19, Salmonella ve Brusella aglütinasyon test sonuçları, anti-nükleer antikor, anti-çift sarmal DNA, kemik iliği aspirasyon sonucu kaydedildiBulgular: Hastaların 28'i kız, 30'u erkekti. Yaş ortalamaları kızlarda 6,5 (±4,0) yıl, erkeklerde 8,8 (±3,6)'di. En sık yakınmalar hâlsizlik, ateş, üst solunum yolu enfeksiyonu yakınmaları (hapşırık, aksırık, gözlerde sulanma, öksürük, ateş), kemik ağrısı, dispeptik yakınmalar ve morluktu. En sık fizik muayene bulguları solukluk, lenfadenopati, splenomegali, ateş, hepatomegali, üst solunum yolu enfeksiyonu bulguları, ekimozdu. Bisitopeni nedenleri %48,3 akut lösemi, %5,2 B12 vitamin eksikliği, %3,4 Brusella enfeksiyonu, %1,7 depo hastalığı, %1,7 portal hipertansiyon, %1,7 aplastik anemi, %1,7 sistemik lupus eritematozus, %36,2 bilinmeyen olarak saptandı