The in vitro activity of meropenem on Pseudomonas aeruginosa, Klebsiella pneumoniae and Aacinetobacter species

Meropenemin Pseudomonas aeruginosa, Klebsiella pneumoniae ve Acinetobacter kökenlerine in vitro etkinliği

Feriha ÖZKAN, Süleyha HİLMİOĞLU, Bedii NAFİLE, Abdullah HASSAN, Mehmet Ali ÖZİNEL, Alper TÜNGER, Cengiz ÇAVUŞOĞLU

Abstract

Efficacy of meropenem against Pseudomonas aeruginosa. Klebsiella pneumoniae and Acinetobacter species were investigated by agar dilution method. Totally 270 P. aeruginosa and 62 Acinetobacte strains isolated from patients with nosocomial infection were enrolled the study. $MİK_{50}$ and $MİK_{90}$ values of meropenem against these strains were found 1 $mu$g/ml and 16$mu$g/ml (range 0.06-256 $mu$g/ml), in P. aeruginosa. 0.06 $mu$g/ml and 0.25 $mu$g/ml (range 0.06-0.2 $mu$g/ml) in K. pneumoniae and 1 $mu$g/ml and 8 $mu$g/m (range 0.06-0.32 $mu$g/ml) in Acinetobacter spp, respectively.

Özet

Meropenemin hastane infeksiyonu etkeni olarak soyutlanan Pseudomonas aeruginosa. Klebsiella pneumoniae ve Acinetobacter türlerine in vitro etkinliğinin araştırılması amacıyla 270 P. aeruginosa ve 62 Acinetobacte kökeninin meropenem duyarlılıkları agar dilüsyon yöntemi ile incelendi. Meropenem için P. aeruginosa kökenlerinde$MİK_{50}$ 1 $mu$g/ml ve $MİK_{90}$ 16 $mu$g/ml (aralık 0.06-256 $mu$g/ml), K. pneumoniae kökenlerinde $MİK_{50}$ 0.06 $mu$g/ml ve $MİK_{90}$ 0.25 $mu$g/ml (aralık 0.06-0.2 $mu$g/ml) ve Acinetobacter türlerinde de MlK50 1$mu$g/ml ve $MİK_{90}$ 8 $mu$g/ml (aralık 0.06-0.2 $mu$g/ml) olarak belirlendi