Ceragenins exhibiting promising antimicrobial activity against various multidrug resistant Gram negative bacteria

Abstract

Ceragenins are novel promising agents for the treatment of infections caused by multi-drug resistant microorganisms.Since colistin resistance has become a worldwide problem, the need for new treatment agents has been increasingsteadily. Therefore, this study aimed to investigate in vitro antimicrobial activities of ceragenins (Cationic Steroid Antibiotics)(CSA-8, CSA-13, CSA-142 and CSA-192) against multidrug resistant Gram negative isolates from Turkey. Experimentswere performed by using broth microdilution method against Klebsiella pneumoniae, Morganella morganii, Pseudomonasaeruginosa and Stenotrophomonas maltophilia isolates. All microorganisms except for three isolates were identified asmultidrug resistant. Among tested ceragenins, CSA-13 showed the best results (MIC: 8-64 µg/ml). Nevertheless, the antimicrobialactivity of CSA-8 was not significant. In conclusion, ceragenins appear to be a good candidate as antimicrobialtherapy in the presence of multidrug (including colistin) resistant microorganisms.