Intra-day changes in the levels of biochemistry parameters

Abstract

Objectives: People mostly live in the nonfasting state during a normal 24-h cycle. This study aims to compare the levels of 18 biochemical parameters during different hours of the day. Methods: A total of 18 biochemical tests of patients who visited outpatient clinics only once between January 1, 2010, and December 31, 2019, were evaluated at the Hatay Mustafa Kemal University (HMKU) Central Laboratory by using hospital database information. The tests are albumin (Alb), aspartate aminotransaminase (AST), alanine aminotransaminase (ALT), alkaline phosphatase (ALP), amylase, blood urea nitrogen (BUN), calcium (Ca), total cholesterol (TC), creatine kinase (CK), creatinine (Cr), gamma-glutamyltransferase (GGT), glucose, high-density lipoprotein cholesterol (HDL-C), inorganic phosphorus (Pi), iron (Fe), total protein (TP), triglyceride (TG), and lipase. The blood samples of the patient were divided into eight groups according to their collection time as follows: (a) 07:00-07:59, (b) 08:00-08:59, (c) 09:00-09:59, (d) 10:00-10:59, (e) 11:00-11:59, (f ) 12:00-13:59, (g) 14:00-14:59, and (h) 15:00-17:00. Results: A statistically significant difference was found between the groups in terms of all parameters except amylase, GGT, and TP (p