Protective effect of Melatonin and Ganoderma lucidum against the negative effects of extremely low frequency electric and magnetic fields in the periodontal tissues

Abstract

Aim: The purpose of this study was to determine whether extremely lowfrequency electric and magnetic field (ELF-EMF) had any detrimentaleffects on periodontal tissue and to investigate, histologically andimmunohistochemically whether melatonin (MLT) and Ganodermalucidum (GL) had a protective role against these detrimental effects.Methodology: A total of 56 adults, male Wistar Albino rats were usedin this study. Rats were divided into 7 equal groups and exposed to ELFEMF,which was produced by a high voltage source, 8 hours / day for 26days. GL (20 mg / kg / day) and MLT (10 mg / kg / day) were administeredby the oral gavage and intraperitoneal method.Results: Fibrous degeneration in the periodontal membrane,inflammatory cell infiltration, connective tissue fiber organization,dilation, and hemorrhage in the blood vessels changes were determinedin the periodontal tissue of the rats in groups I and IV. A statisticallysignificant difference was determined in the groups treated with MLT andGL (p