Lambda Light Chain Cast Nephropathy: A Case Report

Abstract

Excess production of free light chains is due to underlying plasma cell dyscrasia or a lymphoproliferative disease. When the degradation capacity by proximal tubule is exceeded as a result of overproduction, the excess light chains produced reach the distal tubule and cause accumulation, causing deterioration in kidney functions. Although this condition, called cast nephropathy, is most seen in multiple myeloma, it may also be associated with Waldenström macroglobulinemia and lymphomas.