Comparison of recovery profiles of sevoflurane and desflurane inhalation and remifentanil infusion in long-lasting craniotomy operations

Sevofluran, desfluran inhalasyonu ve remifentanil infüzyonunun uzun süren kraniotomi olgularında derleme özellikleri açısından karşılaştırılması

Abstract

This study aimed to compare remifentanil infusion, desflurane and sevoflurane anesthesia regarding hemodynamic parameters, recovery and side effects in craniotomy patients who were operated for intracranial masses (> 4 hr). Forty-five ASA l-lll patients who were between 15-75 years old with Glasgow coma scale (GCS) were 15 were divided into three equal groups. Following standard monitorization, 1ug kg'^ remifentanil, 5-7 mg kg"^ tiopental sodium and 0,9 mg kg"' rocuroni-um were used for induction of anesthesia. In group S 1-2 % sevoflurane, in group D 3-4 % desfluran and in group R 0,2 - 0,4 ug kg"' remifentanil were used for the maintenance of anesthesia with 50 % O2N2O. Systolic and diastolic blood pressures, and the heart rate of the patients were recorded preoperatively and during the postoperative 60 minutes. After cessation of anesthesia, times of spontaneous respiration and eye opening, extubation, response to verbal commands, Aldrete score >9 with nausea-vomiting symptoms were recorded. Systolic and diastolic blood pressures were higher in group D when compared with group R (p

Özet

Qahsmada, kafa icj yer kaplayan lezyonu nedeniyle kranyotomi uygulanan olguiarda (> 4 saat) remifentanil infuzyonu, desfluran, sevofluran anestezisini, he-modinami, derlenme donemi ve yan etkiler bakimin-dan karsjlastirmayi amagladik. 15-75 yas, ASA l-lll, Glaskow koma skalasi (GKS) 15 olan 45 hasta rasgele uc e§it gruba aynldi. Premedi-kasyon, standart monitorizasyondan sonra, 1 mg kg" 1 remifentanil, 5-7 mg kg"^ tiyopental sodyum, 0,9 mg kg"1 rokuronyum uygulandi. idamede; %50 02-N2O ile Grup S'de; %1-2 sevofluran, Grup D'de; %3-4 desfluran ve Grup R'de; 0,2 -0.4 mg kg"'' dk"1. remifentanil infuzyonu kullanildi. Peroperatif ve posto-peratif 60 dakika suresince sistolik (SAB), diyastolik (DAB), kalp atim hizlan (KH) kaydedildi. Anestezi ke-sildikten sonra; spontan soluma, spontan goz agma, ekstubasyon, sozlu emirlere uyma ve Aldrete derlenme skoru >9 oldugu zaman tespit edildi. Bulanti-kus-ma kaydedildi. SAB ve DAB cilt kesisinde grup D'de grup R'ye gore yuksek bulundu. (p