Immunolocalization of fibronectin and transforming growth factor- $beta$ 1 in the thyroid, parathyroid and adrenal glands of male rats treated with carbendazım

Abstract

The aim of this study is was is to evaluate the immunolocalization for fibronectin and transforming growth factor- $beta$ 1 in adrenal, thyroid and parathyroid glands of rats treated with carbendazim. The Swiss albino male rats were exposed to 0, 150, 300 and 600 mg/kg/day carbendazim doses by gavage for 3.5 months. The thyroid, parathyroid and adrenal glands of rats killed by cervical dislocation were removed and paraffin blocks were prepared. Then, the tissue sections stained by the PAP method were examined. The immunreactivity for fibronectin and transforming growth factor- $beta$ were increased in adrenal, thyroid and parathyroid glands in 300 and 600 mg/kg/day groups depending on advancing doses.