Placental structure in the rats: Histological and immunohistochemical studies

Abstract

The aim of this paper is to review the current knowledge of the localization and function of TN (Tenascin) and type IV collagen and EGF (Epidermal Growth Factor) and EGFR (Epidermal Growth Factor Receptor) in normal rat placenta formation. In this study, immunolocalization of ECM (Extracellular matrix) components such as TN and type IV collagen and EGF and its receptor in the placenta of Wistar albino rats were determined. Therefore, the samples of placenta obtained from rats on days 10, 12, 14, 16, 18, 20 and 21 of gestation were evaluated morphologically; fixed and stained with H&E for histology method for immunohistochemistry. Besides, during the experiment, body weights of all rats were recorded.Morphological and histological investigation showed that there were changes in placental histology with placental development. Time- and region dependent changes in the immunolocalization of TN, type IV collagen, EGF and EGFR were determined in the placentas of rats during their gestational period.