Factors influencing glycemic control in children with type 1 diabetes

Abstract

Introduction: There are a plenty of factors influencing glycemic control in children with type 1 diabetes mellitus (DM). The aim of this study was to determine the factors influencing metabolic control in children with type 1 DM. Materials and Method: The study was performed in 200 children with type 1 DM between the ages 6 months to 18 years. This study was conducted by interviewing individually with the children and their families and completing the questionnaires related to their demographic features and data associated with their illness. The laboratory findings and medical information of the patients from the charts were also retrospectively recorded. Results: There were a total of 200 patients including 104 (52%) girls and 96 (48%) boys. The mean age of the patients was 11.7 (±4.26) years. The mean duration of diabetes was 3.8 years (6 months to 14 years). Eighty-nine percent of all patients and all of the patients between 12 and 18 years of age were on intensive insulin therapy. Mean insulin dose was 0.84±0.19 units/kg/day. The mean HbA1c value was 8.8%. Body mass index (BMI) mean z-score was -0.06±1.19. There were no correlations between HbA1c and the duration of diabetes or age although a positive correlation was found with insulin dose (r=0.27 p

Özet

Giriş: Tip 1 diyabetli hastalarda glisemik kontrol etkileyen çok sayıda faktör söz konusudur. Bu çalışmada, tip 1 diabetes mellituslu (DM) çocuklarda metabolik kontrolü etkileyen faktörleri belirlemek amaçlanmıştır. Gereç ve Yöntem: Tip 1 DM tanısı ile takip edilen 0-18 yaş arasında 200 hastaya sosyodemografik özelliklerini ve hastalıkla ilgili bilgilerini içeren sorulardan oluşan bir anket formu uygulanmış ve hasta dosyaları geriye dönük olarak incelenerek hastaların laboratuvar bulguları ve tıbbi tedavi bilgileri elde edilmiştir. Bulgular: Çalışmaya 104 (%52) kız ve 96 (%48) erkek olmak üzere toplam 200 tip 1 diyabetli çocuk dahil edilmiştir. Hastaların ortalama HbA1c değeri %8,8 (6-15), ortalama yaşı 11,7 (±4,26) yıl ve ortalama diyabet süresi 3,8 yıl (6 ay-14 yıl) olarak bulunmuştur. Tüm hastaların %89’u, 12-18 yaş arası hastaların ise tamamı yoğun insülin tedavisi kullanmakta idi. Ortalama insülin dozu 0,84±0,19 ü/kg/gün ve vücut kitle indeksi (VKİ) z-skor ortalaması -0,06±1,19 olarak saptandı. HbA1c ile insülin dozu arasında pozitif korelasyon olduğu (r=0,27 p