Hyper IgM syndrome

Abstract

The hyper IgM syndrome is a rare, inherited immune deficiency disorder and somatic. The most common form of hyper IgM syndrome is of X-linked inheritance and caused by CD40 ligand gene mutations. Patients usually become symptomatic before the second year of life, with recurrent pyogenic and opportunistic infections such as P. carinii and Cryptosporidium.In this article, we reported three cases that have recurrent infections and reviewed the clinical features of this rare disease.