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Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 1997 / Cilt: 3 - Sayı: 3

Increased frequency of sister chromatid exchange and mitotic index in women using oral contraceptives

Oral konstraseptif kullanan kadınlarda artmış kardeş kromatid değişimi ve mitotik indeks sıklığı

Mustafa SOLAK, Tevhide FISTIK, Selman LAÇİN, Faik KOYUNCU, Yıldız UYAR

Pages
439–441
DOI
—

Abstract

! OBJECTIVE: In this study, we tried to investigate acute mutagenic effects of monophasic oral j contraceptives in standard doses on sister chromatid exchange and Mitotic index. i STUDY DESING: 35 women using oral contraceptives for three months were included into the study. I They were given 0,03 mg of ethinyl estradiol and 0,3 mg of norgestrel continuously for three weeks i and 75 mg ferrous for the fourth week. Sister chromatid exchange and mitotic index frequencies were recorded from peripheral blood leucocytes in a blinded fashion. RESULTS: Frequencies determined at the end of the third month were significantly increased (p

Özet

! OBJECTIVE: In this study, we tried to investigate acute mutagenic effects of monophasic oral j contraceptives in standard doses on sister chromatid exchange and Mitotic index. i STUDY DESING: 35 women using oral contraceptives for three months were included into the study. I They were given 0,03 mg of ethinyl estradiol and 0,3 mg of norgestrel continuously for three weeks i and 75 mg ferrous for the fourth week. Sister chromatid exchange and mitotic index frequencies were recorded from peripheral blood leucocytes in a blinded fashion. RESULTS: Frequencies determined at the end of the third month were significantly increased (p