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Journals / FABAD Journal of Pharmaceutical Sciences / 2001 / Cilt: 26 - Sayı: 1

Bazı sübstitüe tiyosemikarbazidlerin ve 2,5-Disübsütitüe-1,3,4-Tiyadiazollerin antibakteriyal, antifungal ve antimikobakteriyal aktiviteleri

Antibacterial, antifungal and antimycobacterial activities of some substituted thiosemicarbazides and 2,5-Disubstituted-1,3,4-Thiadiazoles

N. Nehir GÜLERMAN, Habibe ERDENİZ, Muammer KİRAZ, Sevim ROLLAS

Pages
1–5
DOI
—

Abstract

In this research, some 1-[4-(acetylamino)benzoyl]-4-substituted thiosemicarbazides and 5-[4-(acetylamino)phenyl]-2-substitutedamino-1,3,4-thiadiazoles were screened for antibacterial, antifungal and antimycobacterial activities. The minimum inhibition concentration (MIC) values of compounds have been determined using the microdilution method and the BACTEC 460 radiometric system. Some of the compounds were found to be active against Mycobacterium fortuitum strain and 5-[4-(acetylamino)phenyl]-2-ethylamino-l,3,4-thiadiazole showed a MIC value (16 µg/mL) equivalent to that of tobramycin, which was used as the standard compound.

Özet

Bu çalışmada, bazı 1-[4-(asetilamino)benzoil]-4-sübstitüe tiyosemikarbazidler ve 5-[4-(asetilamino) fenil]-2-sübstitüeamino-1,3,4-tiyadiazollerin antibakteriyal, antifungal ve antimikobakteriyal aktiviteleri incelenmiştir. Bileşiklerin minimum inhibisyon konsantrasyonları (MİK) mikrodilusyon metodu ve BACTEC 460 radyometrik sistemleri kullanılarak tayin edilmiştir. Bileşiklerden bazıları Mycobacterium fortuitum suşuna karşı etkin bulunmuş ve 5-[4-(asetilamino)fenil]-2-etilamino-l,3,4-tiyadiazol standart madde olarak kullanılan tobramisine eşit (16 µg/mL) MİK değeri göstermiştir.