Detection of Human Herpesvirus-6 in Cerebrospinal Fluid of Patients with Meningococcal Meningitis— Report of Two Cases from Gaziantep, Turkey

Abstract

Meningitis is a very severe and life-threatening clinical table. For rapid diagnosis of meningitis, DNAs or RNAs of the possible pathogens are investigated using syndromic panel-based testing, and it is very commonly used for early guidance to therapy in recent years. Depending on the specificity and sensitivity of the tests, it is possible to detect more than one pathogen. In this research, cerebrospinal fluid of two patients with early diagnosis of meningitis based on their clinical findings were tested using BioFire FilmArray Multiplex PCR (Biomerieux, France). Neisseria meningitidis and human herpesvirus-6 were codetected. For further evaluation of clinical meaning of this codetections, this case report is presented.