Decrease of serum biomarker of type II Collagen degradation by intra-articular injection of an autologous plasma-rich-platelet in patients with unilateral primary knee osteoarthritis

Abstract

Objective: This study aimed to evaluate the effect of one dose of intra-articular injection of (PRP) in the knee joint on a specific osteoarthritis (OA) serum biomarker of cartilage degeneration, Collagen 2-1 , over a short period of 3 months. The aim extended to clarify the effect of PRP on the functional status of the osteoarthritic knee joint. Material and Methods: Sixty patients with primary unilateral knee OA were enrolled in this study. They were subdivided according to Kellgren-Lawrence grading scale (KL) into (Group ?): including patients with KL grade =3. Patients were asked to complete the Western Ontario and McMaster Universities Arthritis Index (WOMAC) Score. PRP was prepared and injected immediately into the affected knee. Serum Coll2-1 concentration was measured by enzyme-linked immunosorbent assay (ELISA) kit pre and 3 months after PRP injection. Results: Significant reduction in S.Coll2-1 concentration in primary knee OA patients; (p