Semaphorin3A: A potential therapeutic tool in immune-mediated diseases

Abstract

The significance of semaphorin3A (sema3A) in regulating immune-mediated inflammation is widelyreported. There are multiple mechanisms involved in the process of sema3A-mediated regulation.One of them is the ability of sema3A to maintain a sufficient regulation of both T-cell and B-cell acti-vation. Because it is involved in the pathogenesis of many autoimmune, infectious, and malignant dis-eases, sema3A turns to be a promising therapeutic tool to be studied and applied in these diseases.