Primary hyperparathyroidism and Gougerot disease

Abstract

Primary hyperparathyroidism (PHPT) is a common endocrine disorder caused by the overactiva-tion of the parathyroid glands due to the autonomous production of the parathyroid hormone(PTH). The resultant hypercalcemia leads to a myriad of symptoms. Here we report the case ofa 54-year-old female with a previous diagnosis of Gougerot disease, in whom clinical (diffusebone pain, asthenia polydipsia, and polyuria) and laboratory features (calcium level, 3.1 mmol/L;phosphate level, 0.55 mmol/L; alkaline phosphatase level, 70 U/L; and intact PTH level, 1028.9pmol/L) prompted the diagnosis of PHPT caused by a parathyroid adenoma as confirmed byanatomopathology. After treatment with renal replacement therapy, intravenous fluids and zo-lendronic acid, and subtotal parathyroidectomy, the patient status improved, with normal lab-oratory tests. However, the fortuitous nature of the association between Gougerot disease andPHPT as well as the physiopathological links between these two diseases remain to be specified.