Malignant Transformation of Mature Cystic Teratomas: A Retrospective Analysis of 181 Cases

Abstract

Objective: Mature cystic teratoma (MCT) constitutes 20% of all ovarian tumors and is the most prevalent ovarian germ cell tumor. Notably, any of its component tissues may undergo a malignant transformation (MT). This study aimed to retrospectively analyze the malignancies that arise from MCT of the ovary.Methods: Data of histopathological analysis of ovarian masses resected from adult patients and diagnosed at our laboratory be-tween January 2012 and December 2018 were reviewed.Results: Of our 181 cases, 7 (3.86%) were detected to have MT. Among the MT cases, five had papillary thyroid carcinoma, one had squamous cell carcinoma, and one had a strumal carcinoid.Conclusion: The diagnosis of malignancies arising from MCT is crucial to decide on the follow-up and treatment options for pa-tients. Reporting data obtained from cases that demonstrate MT will aid in the pre- and postoperative management of patients.