Association of Primary Sarcopenia with Serum MMP2, TIMP2 Levels, and MMP2/TIMP2 Ratio

Abstract

Objective: Our aim is to evaluate the association of serum matrix metalloproteinase (MMP2), tissue inhibitor of metalloproteinase (TIMP2) levels, MMP2/TIMP2 ratio, SARC-F with primary sarcopenia, and to investigate the coexistence of primary sarcopenia and osteoporosis in geriatric population. Materials and Methods: A total of 80 geriatric patients (41 sarcopenic patients) were included in the study. Patients with secondary sarcopenia were excluded. By SARC-F questionnaire, patients who were at risk for sarcopenia were found as mentioned by EWGSOP2. Serum MMP2 and TIMP2 levels were analyzed by ELISA method. Dual energy X-ray absorptiometry (DEXA) was used for the diagnosis of osteoporosis. Results: The SARC-F score of the sarcopenia group was statistically significantly higher and the incidence of osteoporosis was higher in this group than the group without sarcopenia (p