How to Treat Osteoporosis in Octogenarians?

Abstract

Objective: There are few studies investigating the efficacy of anti-osteoporotic drugs in the oldest old. This study aimed to compare the effectiveness of osteoporosis treatment among individuals older and younger than 80 years of age. Materials and Methods: A total of 257 patients with osteoporosis, aged 65 and over, 234 women and 23 men, were included in the study. Sixtyfive of the patients were aged 80 years and older. Seventy-four participants received alendronate, 93 received zoledronic acid, and 90 received denosumab. Dual-energy X-ray absorptiometry scans were performed at baseline and at month 24. Results: The proportion of the participants receiving glucocorticoid was higher in the under 80-age group. Bone mineral density (BMD) changes were similar between the