Mitotic Spindle as Therapeutic Target for Tetraploid Cancer Cells

Abstract

Tetraploidy constitutes a genomically metastable state that drives oncogenesis by leading aneuploidy. Tetraploidsub-population is frequently found in pre-neoplastic lesions. This particular population is relatively more resistantagainst DNA damaging agents and in consequence, it is important to selectively target tetraploid cancer cells. Here,we listed all the studies that targeted preferentially tetraploid tumors cells focusing on mitosis machinery, essentiallythe spindle pole apparatus and the spindle assembly checkpoint pathways..