A Meta-Analysis of the Prognostic Value of AbnormallyExpressed lncRNAs and Correlation with ClinicopathologicalCharacteristics in Glioma

Abstract

Objectives: Abnormal expression of lncRNAs are involved in the occurrence and development of glioma. Thus, weconducted a meta-analysis to clarify the prognostic value of lncRNAs in glioma integrally. Methods: Pubmed, Web of Science, Embase, Cochrane Library, Clinical Trial.gov and Trip database were searched. Haz ard ratio (HR) and 95% confidence intervals (CI) were calculated in the analysis of prognostic indicators. Odds ratio (OR)and 95%CI were applied to estimate the association between lncRNAs and clinicopathological features. Results: The expression level of lncRNA was significantly correlated with the OS rate of glioma patients (HR=1.29,95%CI: 1.03-1.61, p=0.03). The low expression of CASC2 (HR=0.42, 95%CI: 0.27-0.66, p=0.0001) showed a poor prog nosis of glioma patients. MALAT1 (HR=1.42, 95%CI: 0.38-5.29, p=0.60), HOTAIR (HR=1.70, 95%CI: 0.69-4.21, p=0.25) andTUSC7 (HR=1.81, 95%CI: 0.87-3.75, p=0.11) have no statistical significance for the prognosis of glioma patients. The highexpression of lncRNA was related to WHO staging (OR=0.31, 95%CI: 0.19-0.50, p