Calcified Coronary Lesions in Diabetes – Culmination ofDyslipidaemia and Inflammation

Abstract

Objectives: Cardiovascular diseases are the major cause of mortality amongst diabetic patients.This study was conducted to compare anthropometric, haematological and lipid variables in diabetic and non-diabeticIndians. The presence of coronary calcifications on the angiogram was further associated with above variables. Methods: Prospective study in 1000-bedded hospital in North-India, comprising 105 (30 diabetic, 75 non-diabetic)patients undergoing coronary angiography. Hypertension, smoking, alcohol intake, statin >6 months, previous MI wereexcluded. Lipid profile, HbA1c, BMI, waist-hip ratio, complete blood count, mean platelet volume (MPV), was measured.Continuous variables were correlated using correlation coefficients, and compared between diabetes and coronary calcification groups, using a t-test. Chi-square-test used for associating diabetes with coronary calcifications. Results: Triglyceride-HDLc-ratio, Neutrophil-Lymphocyte-Ratio, WHR and MPV most significantly differed betweendiabetics and non-diabetics (p