Current Pharmacological Approach to ARDS: The Place of Bosentan

Abstract

Acute respiratory distress syndrome is characterized by dyspnea at presentation, tachypnea on physicalexamination, findings of bilateral infiltration in chest radiography, refractory hypoxia, and high mortality.Although the main treatment approach is to address the underlying disease, there are also pharmacologicaland nonpharmacological options for supportive treatment. There is currently no pharmacological agent withproven efficacy in this syndrome, and many drugs are being studied for this purpose. One of these is theendothelin receptor antagonist bosentan.