Journals / Eurasian Journal of Medicine / 2021 / Cilt: 53 - Sayı: 2
Anti-Apoptotic Effects of Resistance Training and Tribulus Terrestris Consumption in the Heart Tissue of Rats Exposed to Stanozolol
- Journal
- Eurasian Journal of Medicine
- Pages
- 79–84
- DOI
- —
Abstract
Objective: Nowadays, the use of energetic substances has become a complex problem in sports, such thatthe role of anabolic-androgenic steroids is undeniable. This study aimed to investigate the antiapoptotic effectof resistance training and Tribulus terrestris in the heart tissue of rats exposed to stanozolol.Materials and Methods: 35 rats divided into 7 groups including (1) sham , (2) stanozolol-treated, (3)stanozolol+50 mg/kg Tribulus terrestris-treated, (4) stanozolol+100 mg/kg Tribulus terrestris-treated, (5)stanozolol+resistance training-treated, (6) stanozolol+resistance training+50 mg/kg Tribulus terrestris-treated, and (7) stanozolol+resistance training+100 mg/kg Tribulus terrestris-treated. During 8 weeks, groups 2-7received 5 mg/kg stanozolol per day peritoneally; groups 5-7 performed resistance training for 3 sessions perweek; and groups 3, 4, 6 and 7 received daily doses of Tribulus terrestris peritoneally.Results: Stanozolol administration significantly increased the BAX, BCL-2, P53, and caspase 3 and BAX/BCL2 ratio (P < .001). Resistance training, 100 mg/kg Tribulus terrestris administration, 50 mg/kg Tribulus terrestrisadministration, resistance training+100 mg/kg Tribulus terrestris administration, and resistance training+50mg/kg Tribulus terrestris administration significantly decreased BAX, BCL-2, P53, and caspase 3 levels andBAX/BCL-2 ratio (P < .001); however, stanozolol+resistance training+100 mg/kg Tribulus terrestris administration caused more decrease than stanozolol+resistance training+50 mg/kg Tribulus terrestris administrationin BAX (P < .001).Conclusion: Resistance training and Tribulus terrestris administration alone appear to have antiapoptotic effects; however, resistance training combined with Tribulus terrestris administration, especially at higher doses,have more desirable effects than resistance training or Tribulus terrestris administration alone on the apoptosismarkers.