The Mean Platelet Volume to Lymphocyte Ratio: A New Prognostic Marker in Resected Gastric Cancer

Abstract

Objectives: Gastric cancer is the fourth most common cancer. Inflammation is a crucial component of tumor progression.Platelet-to-Lymphocyte Ratio (PLR) is a prognostic indicator in many cancer types. Mean Platelet Volume (MPV)is a parameter that reflects platelet function and activity. In this study, we aimed to investigate the prognostic value ofMean Platelet Volume to Lymphocyte Ratio (MPVLR).Methods: Eighty patients who underwent curative resection between January 2014 and December 2018 were includedin the study. Clinicopathological parameters and laboratory analyzes of the patients were obtained from computerrecords retrospectively. MPVLR cut off value was determined via receiver operating characteristic (ROC) curve analysis(low MPVLR: 4.30). MPVLR and clinicopathological characteristics were analyzed by univariate andmultivariate analysis.Results: Median survival (OS) was 24 months, and median disease-free survival (DFS) was 16 months. A significant correlationwas found between MPVLR and gender (p=0.036), lymphocyte count (p