Preoperative Prognostic Nutritional Index is a Strong Predictorof Survival in Patients with Localized Soft Tissue Sarcoma

Faysal DANE, Özkan ALAN, Bülent EROL, Zerrin ÖZGEN, Tuğba BAŞOĞLU, Hüseyin Kemal TÜRKÖZ, Selver IŞIK, Nazım Can DEMİRCAN, Özlem ERCELEP, Perran Fulden YUMUK, Rukiye ARIKAN, Tuğba Akın TELLİ, Nisanur SARIYER, Alper YAŞAR, Abdussamet ÇELEBİ, Ömer SOFULLU

Abstract

Objectives: Prognostic nutritional index (PNI) is an inflammation-based score which was found to be predictive ofsurvival for different types of cancer. Aim of present study is to investigate the association between PNI and survivaloutcomes in patients with soft tissue sarcoma (STS) operated with curative intent. Methods: We retrospectively collected data of 86 patients with localized STS. Preoperative PNI was calculated with thefollowing formula:10×serum albumin (g/dL)+0.005×total lymphocyte count (per mm3 ). Patients were classified into 2groups based on median PNI value. Results: Median age was 52.5 (18-86) years. There were 49 male and 37 female patients. Most common histology wasliposarcoma (26.7%). Our cohort mainly included stage 3 (69.8%) and grade 3 (66.3%) tumors. Radiotherapy and chemotherapy were applied to 69.8% and 48.8% of patients, respectively. Median value of PNI was 48.2 (25.5-68.0). Medianfollow-up duration was 25 months (3-120). Median overall survival (OS) was 84.6 months (95% CI, 72.0-97.3). MedianOS of patients with high PNI (≥48.2) was significantly longer than patients with low PNI (