Primary Signet-ring Cell Carcinoma of Colorectal Origin: A Poor Prognostic Entity

Abstract

Objectives: In this retrospective study, we aimed to evaluate the clinicopathologic characteristics and survival out comes of colorectal cancer patients with signet-ring cell component. Methods: 2673 patients diagnosed with colorectal cancer who presented to two different institutions from 2004 to2019 were investigated. A total of 75 patients with primary signet-ring cell component were included in the study. Results: A total of 75 patients with primary signet-ring cell component were included in the study. 49 (65.3%) werepatients with signet-ring cell components more than 50%, 26 (34.7%) were patients with signet-ring cell componentsless than 50%. At the time of diagnosis, 8 (10.7%) patients had Stage 1-2, 53 (70.7%) patients had Stage 3 and 14 (18.6%)patients had Stage 4 disease. The mean follow-up period of the patients was 54 months. Median overall survival (mOS)was 28.5 months. The mOS of patients who developed metastasis at the time of diagnosis was 9.3 months and mOS ofpatients without metastasis was 36.5 months. Conclusion: It was observed that primary signet-ring cell carcinomas were mostly seen in males and localized in leftcolon and had a worse prognosis than classical adenocarcinomas.