A Snapshot of Oral Microbiota in Patients with Colorectal Cancer

Mutlu HAYRAN, Derya KARAKOÇ, Engin YILMAZ, Deniz Can GÜVEN, Annika BRİNKMANN, Andreas NİTSCHE, Alpaslan ALP, Suayip YALÇIN, Omer DİZDAR, Koray ERGUNAY, Fatma Nur KİTTANA, Yakut AKYON

Abstract

limited. Based on this, we aimed to investigate the composition of oral microbiota in CRC and to compare them withhealthy controls. Methods: Saliva samples from 32 patients who were diagnosed with CRC and from 32 healthy controls in the same agegroup were evaluated in this study. Bacterial populations were identified through the multiplication of partial 16S rDNAsequences and comparison with databases after next-generation sequencing (Illumina MiSeq). Results: In family-level examinations, the relative abundance of Pasteurellaceae was decreased and that of Neisseriaceae was increased in patient group (p=0.008 and p=0.036, respectively). The relative abundance of Bacillales showeda negative correlation with disease stage (r=-0.638, p