Experience of Treatments of Amanita Phalloides-induced Fulminant Liver Failure with Molecular Adsorbent Recirculating System and Therapeutic Plasma Exchange

Abstract

Objective: To evaluate the effects of molecular adsorbent recirculating system (MARS) and therapeutic plasma exchange (TPE) on patients with amanita phalloides-induced fulminant liver failure. Material and Methods: We retrospectively analyzed nine cases of amanita phalloides poisoning where MARS and/or TPE was applied. Results: The survival rate for the nine patients in this study was 66.7%. Patients who received both MARS and TPE therapies experienced higher survival rates than those who received MARS or TPE alone (100% vs 0%, 50%). A single session of TPE produced greater improvements in ALT (-58.6% vs -12.5%), AST (-44.2% vs -26.9%), total bilirubin (-44.4% vs -12.5%), and PT (-51.2% vs -4.89%) compared to a single session of MARS (all p