Güneydoğu anadolu bölgesindeki non-hodgkin lenfomalar

Hüseyin BÜYÜKBAYRAM, Fahri YILMAZ, Adem ARSLAN, Ali Kemal UZUNLAR, Mehmet YALDIZ, Mehmet ÖZAYDIN

Abstract

Purpose: In this study it was aimed to analyse the non-Hodgkin lymphomas of Southeastern Turkey retrospectively. Material and methods: Between the years 1984 and 1995, 185 patients with non-Hodgkin lymphoma were retrospectively reviewed in The Pathology Department of Dicle University Medical School. All of the cases were classified according to the Working Formulation. Results: Of all cases, 105 (56.8%) were nodal lymphoma and the remaining 80 (43.2%) were extranodal lymphoma. One hundred thirty-one (70.8%) cases were male and 54 (29.2%) cases were female and the male-to-female ratio was 2.4. Most of the cases were in the fourth decade. The mean age was 36.3. As to distribution according to grade of all cases, 43 (23.2%) were in low grade, 106 (57.3%) were in intermediate grade, 30 (16.2%) were in high grade and 6 (3.2%) were in a miscellaneous group. Of the cases, 23 (12.4%) were follicular lymphomas and 162 (87.6%) were diffuse lymphomas. Fifty-four (29.2%) cases were diffuse large cell lymphomas, which were the most frequent histopathologic subtype. Conclusion: In conclusion, our values were established to be between the results of developed countries such as Denmark, Hong Kong and USA and developing countries such as China, Gabon and Korea.

Özet

Amaç: Bu çalışmada Güneydoğu Anadolu'da non-Hodgkin lenfomaların retrospektif analizi amaçlandı. Gereç ve yöntem: 1984-1995 yılları arasında Dicle Üniversitesi Tıp Fakültesi Patoloji Anabilim Dalı'nda non-Hodgkin lenfoma tanısı alan 185 olgu retrospektif olarak incelendi. Bulgular: Bütün olgular Working Formulasyonu'na göre sınıflandırıldı. Bütün vakaların 105'i (%56.8) nodal ve 80'i (%43.2) ekstranodal lenfomaydı. Olguların 131'i (%70.8) erkek, 54'ü (%29.2) kadın ve erkek kadın oranı 2.4 idi. Olguların çoğu dördüncü dekattaydı ve ortalama yaş 36.3 idi. Vakaların 43'ü (%23.2) düşük dereceli, 106'sı (%57.3) orta dereceli, 30'u (%16.2) yüksek dereceli ve 6'sı (%3.2) karışık gruptaydı. Olguların 23'ü (%12.4) foliküler ve 162'si (%87.6) diffüz lenfomalıydı. Diffüz büyük hücreli lenfoma 54 (%29.2) vaka ile en sık görülen histopatolojik subtipti. Sonuç: Sonuç olarak verilerimiz gelişmiş ülkeler (Danimarka, Hong Kong ve ABD gibi) ile gelişmekte olan ülkeler (Çin, Gabon ve Kore gibi) arasında tespit edildi.