Kronik hepatit C’de C-Kit pozitif hepatik progenitör hücrelerinin hastalığın takibinde rolü var mı?

Abstract

Objective: The aim of this study was to compare the clinical and pathological properties of cases of hepatitis C virus (HCV) infection with respect to the presence or absence of hepatic progenitor cells positive for the proto-oncogene c-Kit (CD117) in hepatic tissue. Material and Methods: The study was performed on hepatic biopsy specimens from 61 cases with HCV infection. Stained hepatic biopsy slides were examined. Immunohistochemical staining was performed using an anti-c-Kit antibody. The cases were divided into four groups (minimal, mild, moderate and severe according to their total hepatic activity index and into two groups (none/mild, moderate/severe) according to fibrosis grade. Results: c-Kit-positive oval cells were detected in 30 cases(49.1%). There was no statistically significant difference in c-Kit positivity status with respect to the ALT, AST or HCV RNAresults. c-Kit positivity increased with increasing hepatitisgrade (p