Efficacy and Safety of Myrtol® Standardized in theTreatment of Acute and Chronic Rhinosinusitis: A Review of Literature

Abstract

The clinical pattern of rhinosinusitis is based on key symptoms, such as nasal obstruction/congestion, nasal secretion withpostnasal discharge, facial pain with pressure, and impaired sense of smell. Acute rhinosinusitis is a viral infection commonlycaused by impaired paranasal sinus aeration and drainage and can progress to bacterial superinfection. Chronic rhinosinusitisis an inflammatory disease of the sinonasal mucosa with symptoms persisting for more than 12 weeks. This paper aimedto summarize and update the literature related to the use of herbal product Myrtol® standardized in the treatment of acuteand chronic rhinosinusitis. Earlier investigations have demonstrated that Myrtol® standardized has strong secretolytic, se cretomotoric, anti-inflammatory, antioxidative, and antimicrobial effects. Therefore, this study reviewed randomized studiesrelated to its use in the treatment of upper-airway inflammations and discussed the mechanisms of action of this herbal drugon infected nasal and paranasal sinuses mucosa.